This is a step-by-step installation guide. Don't skip a step and read everything, unless you want to risk crashes and instability later on. You have been warned.

The setup has been tested a lot. But keep in mind that there is so much content that it is impossible to test everything. That's why I need your help finding possible bugs and (hopefully not) crashes and freezes. Especially the Expansion Mods have not been tested thoroughly in this specific setup, yet.

Tested with following systems:
Windows 7, GTX 1060 & i5-6500: mostly stable 60 fps with 'High' settings and 1080p.
Windows 10, GTX 1080 & i7-8700k: stable 60 fps at all times with 'Ultra' settings and 1080p.

Requires up to 70 GB of disk space. Recommended to be installed on an SSD.

Wet and Cold:
Might be safe to use without Frostfall. I don't use it anymore and therefore can't recommend it at the moment.

Immersive Patrols:
It leads to consistant fighting on the roads. While that may sound awesome, it really gets old after some time. Add it, if you like that.

EFF (Extensible Follower Framework) or AFT (Amazing Follower Tweaks):
These are the two big Follower Tweak Mods. I can't assure 100% compatibility. Convenient Horses adds horses for followers already and I don't run around with multiple followers.

Realistic Ragdolls and Force:
After testing, I found the difference to be minor to say the least. And since it includes a skeleton file, I chose to not include it to prevent issues from happening.

SkyHUD:
It's actually one of the best mods out there. I just think, that the vanilla HUD is fine.

Total Character Makeover:
Has been in the setup, but is removed now, because I personally prefer Vanilla.

Opulent Outfits:
The new outfits are nice. But I used it so much, that I prefer just Rustic Clothing (a texture mod) and vanilla outfits. I can confirm, that Opulent Outfits runs well with this setup, as long as you use CRF Fix.

Smooth Running Animations:
No incompatibility at all. Compare it with vanilla and choose for yourself.

Legendary Crossbows:
With LOTD's compatibility patch, it should work fine.

Blowing in the Wind:
The compatibility patches are outdated. You can add the mod, but be careful about the patches.

Dawn of Skyrim:
JK's Skyrim is more complete. It is possible to combine Dawn of Skyrim and JK's Skyrim with patches, but don't expect good performance when doing so.

Simply Knock:
Compatible. I just don't use it.

I don't recommend using these Mods:
Campfire / Frostfall / Wearable Lanterns:
Chesko is awesome, but not active since 2016. And these three mods are a common cause of crashes and weirdness in Special Edition. You can use them, if you absolutely want, but I wouldn't recommend it.

(Even) Better Quest Objectives:
Consistancy issues. Some quest objectives that are added by mods feel out of place, if you use EBQO and there are reports of compatibility issues with several mods.

RLO/ELFX/RS:
They cause flickering and graphical weirdness. ELE (Enhanced Lighting for ENB) has less features, but everything you really need. (darker dungeons and weather based interior lighting)

Morrowloot:
There are too many content mods in this setup. Morrowloot is sadly just not compatible.

FNIS:
We already use three patchers (SSEEdit, Wrye Bash and Dyndolod). FNIS is just not worth the increased risk of crashes and bugs in my opinion. And better running animations as well as better quiver placement - which are the main issues I have - are possible without the use of FNIS.

Immersive Citizens:
Crashes, bugs, compatibility issues. The mod is awesome by itself, but just not possible to be used in bigger modded setups without issues.

Simple Auto Unequip Ammo:
I don't see why you would automatically unequip your quiver by switching weapons. You can probably use it safely as well, but sometimes you have to think twice, if a mod actually makes sense and is neccessary.

Hearthfire multiple adoptions:
Bugs when used in the LOTD Safehouse.

SkyTEST:
Reports of crashes, decreased performance and incompatibility with some other mods. Can't confirm or deny, because I am not interested enough into it's features to include it.

Beards:
Caused weird beard clipping for me. Might be different for you.

Enhanced texture detail:
Makes some structures to have very weird textures on a closer look. Probably because of all of the texture mods.

Joy of Perspective:
Incompatible with some mod added armors. Can be patched and I will maybe do that in the future, because I love JoP.

TK Dodge:
Unbalanced.

A Matter of Time(Main File)

Acquisitive Soul Gems Multithreaded(Main File)

Alternate Start(Main File)

Belt-Fastened Quivers(Main File)

Better Dialogue Controls(Main File)

Better MessageBox Controls(Main File)

Flora Respawn Fix(Main File)

Hunters Not Bandits(Main File "Hunters Not Bandits")

iNeed(Main File)
FOMOD Settings:
0. Core
[x] Core Files
1. Extended
[x] None

moreHUD(Main File)

No Spinning Death Animation(Main File "No Spinning Death Animation")

PapyrusUtil SE(Main File)

SKSE64 INI for Lazy Users(Main File "SKSE64 INI PRE DOWNLOAD v1.2")

SkyUI(Main File)

Sovngarde Font Replacer(Main File "Bold")

Stones of Berenziah droppable quest markers(Main File)

The Paarthunax Dilemma(Main File)

Unofficial Skyrim Special Editon Patch(Main File)

Unread Books Glow(Main File "Unread Books Glow SSE 2.2.1")

Andromeda – Unique Standing Stones of Skyrim(Main File)

Consistent Older People(Main File)

Convenient Horses(Main File)

Enhanced Lighting for ENB (ELE)(Main File)

Imperious – Races of Skyrim(Main File "Imperious v724")

Legacy of the Dragonborn SSE(Main File)

Obsidian Weathers and Seasons(Main File)

Realistic Conversations – longer pause between sentences(Optional File "Longer Pause between sentences")

RS Children(Main File)
FOMOD Settings:
Main Patches
[x] USSEP
[x] BS Bruma

Sacrosanct – Vampires of Skyrim(Main File)

Skyrim Alchemy and Food Overhaul(Main File "Assets" and Main File "Core Files and Patches")
FOMOD Settings:
Core Files
[x] Skyrim Alchemy and Food Overhaul (SAFO) Normal Healing
Optional File
[x] SAFO - Imperious 7.24SSE (Healing)

Wonders of Weather(Main File)
FOMOD Settings:
Core
[x] Wonders of Weather

Bring Out Your Dead(Main File)

Carriage and Ferry Travel Overhaul(Main File)

Cutting Room Floor(Main File)

Darkwater Crossing(Main File)

Gildergreen Regrown(Main File)

Helarchen Creek(Main File)

Holidays(Main File)

Insignificant Object Remover(Main File)
FOMOD Settings:
Select
[x] Full

JK's Skyrim(Main File)

Karthwasten(Main File)

Keld-Nar(Main File)

Kynesgrove(Main File)

Landscape Fixes For Grass Mods(Main File)

Shor's Stone(Main File)

Skyrim Better Roads(All 4 Main Files)
FOMOD Settings:
Options
[x] 1. All the Roads and Bridges

Soljund's Sinkhole(Main File)

The Notice Boards(Main File)

Whistling Mine(Main File)

Beyond Skyrim – Bruma(Both Main Files)

Falskaar(Main File)

Helgen Reborn(Main File)

Moon and Star(Main File)

Moonpath to Elsweyr(Main File)

Project AH0(Main File)

Ravengate(Main File)

The Forgotten City(Main File)

The Gray Cowl of Nocturnal(Main File)

Undeath(Main File)

Vigilant(Main File)

Audio Overhaul For Skyrim(Main File "Audio Overhaul Skyrim (3.0.0)")

Soultrap Sound Edit(Main File)

SSE High Quality Music(Main File)

Refer to this when asked to overwrite stuff!:
Static Mesh Improvement (SMIM)overwritesSkyrim Alchemy and Food Overhaul
Ruins Clutter ImprovedoverwritesSMIM
SkylandoverwritesA Quality World Map, SMIM
Riften HDoverwritesSkyland
Realistic Water TwooverwritesSMIM
Skyland – Imperial Forts and DungeonsoverwritesSMIM, Ruins Clutter Improved
Skyland – WhiterunoverwritesSMIM
Skyland – Towns and VillagesoverwritesSMIM
Rustic SoulgemsoverwritesRuins Clutter Improved
Rustic ClothingoverwritesSMIM
Designs of the NordsoverwritesFort Dawnguard HD, Rugnarok, Skyland
Majestic MountainsoverwritesSMIM, Skyland, Riften HD, Realistic Water Two
JS Dragon ClawsoverwritesRuins Clutter Improved
HagravenoverwritesSMIM
Forgotten Retex ProjectoverwritesRuins Clutter Improved
Embers HDoverwritesSMIM
CC's Enhanced Ore VeinsoverwritesSMIM
Bellyaches Animal and Creature PackoverwritesThe Eyes of Beauty, SMIM
Ash Pile RetextureoverwritesRuins Clutter Improved
Animated ClutteroverwritesSMIM, Ruins Clutter Improved
Enhanced Vanilla Trees – BillboardsoverwritesIndistinguishable Billboards, Enhanced Vanilla Trees
High Poly ProjectoverwritesSkyrim Alchemy and Food Overhaul, Ren's HD Shrines, SMIM, Ruins Clutter Improved

A Quality World Map(Main File "8.4 A Quality World Map - Classic with All Roads") <- thanks drizzlol for pointing out, that the "Vivid with Stone Roads" version has the Oldrim Form. I still use Vivid with Stone Roads and haven't encountered issues, yet.

Animated Clutter(Main File)
FOMOD Settings:
[x] Install Everything

Aphophysis Dragon Priest Masks(Main File "Apophysis Dragon Priest Masks")

Ash Pile Retexture Version 2 Fire Glow(Optional File "Ash Pile Retexture Version 2 Fire Glow")

Bellyaches Animal an Creature(Main File)
FOMOD Settings:
[x] Bellyache's Choice

Bellyaches HD Dragon Replacer(Main File)

Birds and Flocks(Main File)

CC's Enhanced Ore Veins(Main File "2k")
FOMOD Settings:
Stone Color
[x] Grey
Glow Type
[x] Glowing Ore <- unless you don't want ore to glow!
New Mined Ore Texture?
[x] Install New Textures
Stone Color
[x] Grey
New Ingot Texture
[x] Install New Textures

Designs of the Nords(Main File)
FOMOD Settings:
[x] Main files

Dragon Priest(Optional File "Dragon.Priest.2k")
FOMOD Settings:
[x] Full (Highly Suggested)

Draugr(Optional File "Draugr.2k")
FOMOD Settings:
[x] Full Install

Dust Effects(Main File)

Embers HD(Main File)
FOMOD Settings:
[x] Embers HD 2K
[x] Fireplaces Add-On
[x] Forges Add-On
[x] Lava Crater Add-On

Enhanced Blood Textures(Main File)
FOMOD Settings:
Main Plugin
[x] Enhanced Blood Textures Main
Effects Distance
[x] Long
Screens and Wounds
[x] No Screen Blood
(rest normal as suggested)

Enhanced Vanilla Trees(Main File and Optional File "Billboards") <- has the Oldrim Form, but works fine
FOMOD Settings:
Main Mod:
[x] ENB <- even if you don't use ENB
[x] Lush Trees (small)
[x] Enhanced tree clutter (Recommended)
[x] Realistic Aspen Trees
[x] Lush Vurts Snow Trees
[x] Install my LODs
BillBoards Generator:
[x] Vanilla Textured Trees
[x] Realistic Aspen Trees
[x] Lush
[x] Lush Vurts Snow trees

Ennead Septims 2k Gold(Main File "2K Gold")

Ethereal Clouds(Main File "2K")

Ethereal Cosmos(Main File "Ethereal Cosmos - Special Edition")

Footprints(Main File)

Forgotten Retex Project(Main File)
FOMOD Settings:
[x] Main files

Fort Dawnguard HD(Main File)

Kyoe's Bang'n Brows(Main File "Replacement - Female" and Main File "Replacement - Male Vanillamatch")

Giant(Optional File "Giant.2k")

Hagraven(Optional File "Hagraven.2k")

HD Road Signs(Main File "2K Version")

High Poly Project(Main File and Update File)

HQ Paper(Main File)

Indistinguishable Billboards(Main File "VANILLA Medium")

JS Dragon Claws(Main File "2k Textures")

LeanWolf's Better-Shaped Weapons(Main File "Standard SE" and Update File "Arrow Update")

Majestic Mountains Main File(Main File "1. Majestic Mountains Main File" and Optional File "1. Majestic Mountains Lod Pack")
FOMOD Settings:
Main File:
Required
[x] Main files
Optionals
[x] Landscape Textures
[x] Moss Rocks
Sun Direction
[x] North (Default)
Compatibility Patches
[x] SMIM
LOD Pack:
Lod Resolution
[x] 1024

Natural Teeth(Main File "Less Yellow") <- or yellow

Raven Rock HD(Main File)

Realistic Water Two(Main File)
FOMOD Settings:
Core
[x] Core Files
Mod Patches
[x] iNeed

Ren's HD Shrines(Main File)
FOMOD Settings:
(keep everything on default or choose preferences)

Riften HD(Main File)

RUGNAROK 2k(Main File "2K")

Ruins Clutter Improved(Main File "Ruins_Clutter_Improved_SE_NMM_v3-0")
FOMOD Settings:
Options
[x] Install Everything

Rustic Clothing(MainFile "2K")

Rustic Soulgems – 2k Unsorted(Main File "2k Unsorted")

See Enchantments(Main File)

skyBirds(Main File)

Skyland(Main File)

Skyland - Imperial Forts and Dungeons(Main File)

Skyland – Standing Stones(Main File)

Skyland – Towns and Villages(Main File)

Skyland – Whiterun(Main File)

Skyrim is Windy(Main File)

Static Mesh Improvement (SMIM)(Main File)
FOMOD Settings:
[x] Everything

Terrain Lod Redone(Main File)

The Eyes of Beauty(Optional File "The Eyes of Beauty - NPC")

Troll(Optional File "Troll.2k")

Veydosebrom(Main File)
FOMOD Settings:
[x] Packed
[x] Vanilla Season
[x] Performance
[x] Dense Landscape <- Disable if slight clipping in some areas is outwheighting the denser grass
[x] 2k Quality
[x] 2k Full

Wispmother(Main File "Wispmother 2x1k")
FOMOD Settings:
[x] Full version - skin with a mesh fabric veil (RECOMMENDED)

Advanced Adversary Encounters(Main File)

Diverse Dragons Collection(Main File)

OBIS Special Edition(Main File)
FOMOD Settings:
[x] Main OBIS Mod
[x] Noticeboard Addon

Splendor(Main File)

Cloaks of Skyrim(Main File)
FOMOD Settings:
[x] Main Version

Heavy Armory(Main File)

Immersive Armors(Main File)

Improved closefaced helmets(Main File)

Royal Armory(Main File)

Unique Uniques(Main File)

Winter is Coming(Main File "WIC Cloaks SSE 2_4")

Zim's Immersive Artifacts(Main File)
FOMOD Settings:
[x] All Artifacts

Alex's Higher Bounty Rewards(Main File "Higher Bounty Rewards")

Apocalypse(Main File)

Civil War Aftermath(Main File)

D13 Faster Get Up(Main File)

Dawnguard Delayed(Main File "Level 30")

Dragonborn Delayed(Main File "Dragonslayer")

Faster Firewood Harvesting(Main File)

Faster Mining Plus(Main File)

Follower Trap Safety(Main File)

Less Dragons(Main File)
ATTENTION!:
The Mod installs 3 .esps. You only want one of them (I recommend the "25" version). DELETE the other two to avoid problems.

Mark of Arkay(Main File) <- Optional. Adds a customizable "Revive" system. I like it, because it's not less immersive than constantly loading saves.

No BS AI Projectile Dodge(Main File)

Ordinator(Main File and Optional File "Thief Skills Rebalance for Ordinator")

Quick Light(Main File)

Realistic AI Detection(Main File "Lite" or "Medium" if you want more challenge. I use Medium.)

Pumping Iron(Main File)

Run For Your Lives(Main File)

Skyrim Skill Uncapper(Main File)

Smilodon(Main File)

Summermyst(Main File)

Thunderchild(Main File)

Uncapper Presets(Main File)
FOMOD Options:
[x] SKSE64
[x] 199
[x] Adjusted
[x] Apocalypse <- if you plan on using a certain autotrigger spell that Apocalypse adds to the game

VioLens(Main File)
FOMOD Settings:
[x] VioLens SE
[x] Loose

Sofia(Main File "BSA")

INIGO(Main File)

Professor Benjamin Doon(Main File)

Always let fixes/patches overwrite other mods! They are patches for a reason.
Be careful to download the right mods. Many of them are not the Main File.

Audio Overhaul - Enhanced Blood Textures(Misc File "Compatibility Patch for Enhanced Blood Textures")

Audio Overhaul - Realistic Water Two(Misc File "Compatibility Patch for Realistic Water Two")

Audio Overhaul - Legacy of the Dragonborn(Misc File "Consistency Patch for Legacy of the Dragonborn")

Audio Overhaul - Obsidian Weathers and Seasons(Misc File "Weather Patch for Obsidian Weathers and Seasons")

Advanced Adversary Encounters Patches(Main File)
FOMOD Settings:
(automatically detects installed mods. No changes needed)

Apocalypse – Ordinator Patch(Optional File "Ordinator Compatibility Patch")

Bruma patch for Convenient Horses(Main File)

Bruma Signs SMIM patch(Main File)

Flora Respawn Fix SE for Beyond Skyrim(Main File)

HD Road Signs – Cutting Room Floor Signs(Optional File "Cutting Room Floor Signs")

Heavy Armory Enchanted(Main File "Heavy Armory Enchanted")

JK's Skyrim - Arthmoor's Patch Pack(Optional File "JK's Skyrim - Arthmoor's Patch Pack")
FOMOD Settings:
Main
[x] Individual Patches
Individual Patches
[x] Bring Out Your Dead Patch
[x] Cutting Room Floor Patch

JK's Skyrim SE CFTO Carriages and Ferry Travel Patch(Optional File "JK's Skyrim SE CFTO Carriages and Ferry Travel Patch")

JK's Skyrim SE Holidays Patch(Optional File "JK's Skyrim SE Holidays Patch")

JK's Skyrim SE Realistic Water Two Patch(Optional File "JK's Skyrim SE Realistic Water Two Patch")

JK's Skyrim SE Thunderchild Patch(Optional File "JK's Skyrim SE Thunderchild Patch")

Landscape Fixes for Grass Mods – Alternate Start LAL Locations(Optional File "Alternate start- LAL Locations")

Landscape Fixes For Grass Mods – Cutting Room Floor Location(Optional File "Cutting Room Floor Locations")

Landscape Fixes For Grass Mods - JK's Skyrim - Towns(Optional File "JK's Skyrim - Towns")

Landscape Fixes For Grass Mods - Patch for Arthmoor's Shor's Stone(Optional File "Patch for Arthmoor's Shor's Stone)

Legacy of the Dragonborn Patches(Optional File "Legacy of the Dragonborn Patches Installer")
FOMOD Settings:
(automatically detects installed mods. No changes needed)

Lexy's LOTD Patches - Improved closefaced helmets for Undeath SSE(Misc File "Improved closefaced helmets for Undeath SSE")

Lexy's LOTD Patches - iNeed Bruma Patch(Misc File "iNeed Bruma Patch")

No Poison Prompt Message SE(Main File)

No Quit Prompt Message(Main File)

Obsidian Weathers for Vigilant(Optional File "Obsidian Weather for Vigilant")

Ordinator Beyond Skyrim Patch(Main File)

RS Children Patches(Main File)
FOMOD Settings:
(automatically detects installed mods BUT...)
IMPORTANT!!!: uncheck Legacy of the Dragonborn in the FOMOD menu. Otherwise, Henry will have a black face.

Skyrim is Windy EVT Patch(Optional File "Skyrim is Windy - Enhanced Vanilla Trees Patch") <- Oldrim Form 43

The Gray Cowl of Nocturnal SSE – HD pack(Main File)

Unofficial Moonpath to Elsweyr Patch(Main File)

Vigilant English Patch(Main File)

Winter is Coming – COS Patch 2_4(Optional File "WIC Cloaks SSE COS Patch 2_4")

Before proceeding, check, if Less Dragons is installed correctly. Delete 2 of the 3 .esps, Less Dragons creates.

Now is also a good point to double check, if your masters are cleaned. Loot will tell you with orange or red font color behing Update.esm, etc. when they are not.

1. Start LOOT and edit the Metadata of following plugins:

• Smilodon - Combat of Skyrim.esp: Load after dD - Enhanced Blood Main.esp
• Andromeda - Unique Standing Stones of Skyrim.esp: Load after Convenient Horses.esp
• NoBSAIProjectileDodge.esp: Load after Smilodon - Combat of Skyrim.esp
• SeeEnchs.esp: Load after Summermyst - Enchantments of Skyrim.esp
• Ordinator - Perks of Skyrim.esp: Load after Audio Overhaul Skyrim.esp and Load after SAFO.esp
• Audio Overhaul Skyrim - RealisticWaterTwo Patch.esp: Load after RealisticWaterTwo.esp
  

2. Let Loot sort the load order. Save, close and restart NMM and Loot. Let Loot sort again, just to be safe.

Here is how to use Mator Smash correctly:

• Open Mator Smash
• Select the SSE profile
• OK
• Keep all Plugins selected
• OK
• Click on the green arrow (Quick Patch)
• Wait until smashing is done
• Close Mator Smash
• Make sure that "Smashed Patch.esp" is activated and at the bottom of the load order
• Done!
  

There is a video by sheson that shows you how to use DynDOLOD. But it is not hard, only takes some time depending on drive type (faster on SSD) and CPU speed.

• Download DynDOLOD (Standalone and Resources)
• Add the Resources archive as a mod in NMM and activate it. Overwrite "Indistinguishable Billboards" but nothing else!
• Unpack the Standalone archive
• Create a shortcut for "TexGenx64.exe" and "DynDOLODx64.exe"
• Right click on the newly created shortcut. Add -sse to the path (Example: "C:\DynDOLOD\TexGenx64.exe" -sse)
• Do the same thing for the other shortcut as well
• Run TexGen
• Choose an Output Path for the textures to create and click "Start"
• (wait till it's done. Takes a few minutes)
• Right click the created folder (textures) and create a .zip archive (for example with 7zip)
• Add the archive as mod in NMM and activate it. Overwrite everything.
• Run DynDOLOD
• Select all worlds
• Choose an Output Path and click on "Medium" (or "High" if you really want it)
• (wait till it's done. Should take 10-20 minutes.)
• Put the created files and folders into a single .zip archive (for example with 7zip)
• Add the archive as mod in NMM and activate it. Overwrite everything.
• Make sure, that DynDOLOD.esm and DynDOLOD.esp exist and are active
• Done!
  

This is optional and still experimental. SSE Engine Fixes includes multiple fixes for different problems of Skyrim like the Double Perk Bug, Save crashes and performance issues.

• Download both Main Files from SSE Engine Fixes
• Install (Part 1) like any other mod
• Extract (Part 2) into the main Skyrim folder
• Open "EngineFixes64.ini" and change "regularquicksaves=false" to "regularquicksaves=true"
• Save the INI and you are done
  
  

Run the Launcher of Skyrim Special Edition at least once to generate ini files.

• Download BethINI and unpack it
• Open the executable
• Check "Recommended Tweaks"
• Click on either High or Ultra depending on your system (I recommend High for GTX 1070 and lower)
• Here are some Tweaks I recommend you doing in BethINI as well:
  
  Under Basic:
  [on] Windowed Mode <- Skyrim runs better windowed
  [on] Borderless <- Windowed Borderless to have the advantages of Fullscreen AND Windowed
  
  Under Detail:
  [96.42] Field of View
  [Low] Godrays <- Almost no visual difference
  [off] Depth of Field <- Optional
  [1024] Shadow Resolution <- 2048 if you really want shadows to be sharper
  [0.25] Sun-Shadow Update Time <- Smoother sun transition
  [1.5] Sun-Shadow Update Threshold <- Smoother sun transition
• Save & Exit BethINI
• Edit Skyrim.ini (found in My Games/Skyrim Special Edition):
  
  [Camera]
  f1st3rdSwitchDelay=0.95; faster transition between first and third person
  iHorseTransitionMillis=0001; faster camera adjustment after dismounting
  
  [Interface]
  fBookOpenTime=200.0; speeds up the opening of books
• Edit SkyrimPrefs.ini (found in My Games/Skyrim Special Edition/):
  
  [AudioMenu]
  fAudioMasterVolume=2.0000; Enables you to adjust the sound values better
  
  [Control]
  bMouseAcceleration=0; Fixes Mouse
  
  [Display]
  iReflectionResolutionDivider=4; A big fps increase and you will barely notice it
  
  [MAIN]
  bSaveOnPause=0
  bSaveOnRest=0
  bSaveOnTravel=0
  bSaveOnWait=0
  

It's now time to start the game. Always start the game via skse64_loader.exe!

• After creating your character, wait a minute, choose a start and interact with the bed
• Wait another minute for alle the mods to be initialized
  

You find the MCM (Mod Configuration Menu) when pressing Escape. There are a lot of options you can do. I recommend the following ones:

• A Matter of Time: Configure the ingame clock (for example: bar, thin and 50% scale)
• ASG Multithreaded: Check everything
• iNeed: Set Timescale 12, disable Horse Needs
• Mark of Arkay: Set your prefered rules for automatic revival
• Sky UI: Here you can set your Hotkeys for Favorite Sets and more
• Summermyst: Enable Fortify Skill Caps
• VioLens: Player Killmove Immunity
  

Go into the magic menu and use the "Obsidian Weathers and Seasons" magic/shout. Enable Seasons FX.

Read the "Helgen Reborn" book. You can get rid of the ASGM book after choosing a specific option in it's menu and throwing it away.

After you are done with the setup, save the game and type in the following command into the console to check, if Skyrim Skill Uncapper works properly:
player.advskill alchemy 100000000
If your Alchemy skill is capped at 100, you are probably experiencing a bug that prevents Skyrim Uncapper from reckognizing the SkyrimUncapper.ini. There are a few possible solutions. Refer to the next section.

This issue seems to be fixed since the most recent SKSE, but I still recommend double checking it in your game!
The DLL of Skyrim Skill Uncapper has a bug. On some systems, everything works fine, but many systems (including mine) have serious problems loading it via SKSE64. Please consider doing this:

• Choose a SkyrimUncapper.ini that allows going over 100.
• Test, if the .ini is correctly loaded every time you start the game. Load a save, open the console and type in "player.advskill alchemy 1000000000000". If Alchemy is capped at 100, it doesn't work. Once it works, it works until you start the game (skse64_loader.exe) again!
• If you encounter problems, do the following:
  

• Install xSHADOWMANx's DLL Loader
• Cut/Remove SkyrimUncapper.dll and SkyrimUncapper.ini from Data/SKSE/Plugins/
• Paste/Put SkyrimUncapper.dll and SkyrimUncapper.ini to Data/Plugins/sumwunn/
• It should work now. But keep testing until you are sure, that it works and report if it doesn't
  

It's quite easy to get an extra 5-10 fps with SSEFixes and another ~5 fps with Fallout 4 ENBOOST (yes, FO4).

• Make sure that you have used all the INI - Tweaks I suggested. Only proceed, if you don't get a stable 60 fps. There is no benefit otherwise.
• Install SSE Fixes if you don't use SSE Engine Fixes. Read the install instructions on that site.
• If you still want more FPS or a more stable 60 fps, follow this guide of dampapx regarding ENBOOST. Also check the comments section there.
  

If you still want to maximize your Skyrim experience, there are some tools that can be very handy.

• Skyrim Savegame Manager: Allows you to set rules to delete and backup your savegames. Really useful, if you have multiple characters or want to minimize the "thumbing" bug in the Save/Load Menu that SkyUI introduces.
• Load Accelerator Guide: If you play on SSD, you can try to reduce loading times by using the FO4 Load Accelerator. It works for SE, if you change a few values. It can be made compatible with ENBOOST by doing this (thanks to ledhead900 for this):
  

Please report any bugs you find.

• Strange behaviour in the Save/Load menu. It is caused by SkyUI and will get fixed one day I hope. Skyrim Savegame Manager and/or SSE Engine Fixes helps.
• Grass clipping with Veydosebrom "Dense Landscapes" option. Fixed for the most part by Landscape Fixes for Grass Mods, but you will still notice it in some areas.
• Some instances of clipping or flying objects with SkyBeRoads, Veydosebrom, Lanterns of Skyrim and Skyrim is Windy. To remove them, click on the clipping object while in the console and type in "disable".
• Belt Fastened Quivers can cause a bug that causes bolts to float in the air. There is a console command to disable quivers being displayed.
• You can recruit multiple followers at a time when using mod - added followers. Doing that can cause weirdness in some places for some reason.
  

Can I update the Mod List midgame?
It is not recommended. Adding mods is less problematic than removing mods. If you really want to, make use of FallrimTools to delete orphaned scripts and rebuild relevant patches.

Why deactivating Autosave?
Loading Autosaves can cause script errors. Without SSE Engine Fixes, you should also avoid Quicksaves.

Which mods are optional?
Every mod is optional. But you have to be more careful during FOMOD settings and when installing the Compatibility Patches.

What is the Oldrim Form problem?
drizzlol and ff7legend pointed out a few potential problems with mods that are using the format of Skyrim 2011. A Quality World Map - Vivid with Stone Roads and Enhanced Vanilla Trees are mods that use this so called Form 43. These three mods didn't cause any problem, yet. But if you are paranoid or want to use the Merge Patches feature of Wrye Bash for some reason, you can skip those three mods until the mod author fixes the issue. If you want to know more about it, check the comments section for information and links.