You can find this setting in \Cyberpunk 2077\red4ext\plugins\mod_settings\user.ini
(it seems the highlighted lines have an error on Nexus side, so make sure you're only changing the value instead of copying the item name)

[EdgerunningConfig]
baseHumanityPool = 250
humanityBonusPerLevel = 0.000000
glitchesThreshold = 60
psychosisThreshold = 20
pcychoCheckPeriod = 1
psychoChance = 15
psychoHeatLevel = 3
alwaysRunAtZero = true
teleportOnEnd = true
frontalCortexCost = 5
systemReplacementCost = 3
eyesCost = 2
musculoskeletalSystemCost = 3
nervousSystemCost = 4
cardiovascularSystemCost = 4
immuneSystemCost = 4
integumentarySystemCost = 3
handsCost = 2
armsCost = 2
legsCost = 2
berserkUsageCost = 6
sandevistanUsageCost = 7
kerenzikovUsageCost = 3
launcherUsageCost = 1
mantisBladesUsageCost = 0
monowireUsageCost = 0
opticalCamoUsageCost = 0
qualityMultiplierCommon = 0.600000
qualityMultiplierUncommon = 1.000000
qualityMultiplierRare = 1.200000
qualityMultiplierEpic = 2.000000
qualityMultiplierLegendary = 3.400000
killCostArasaka = 1
killCostKangTao = 1
killCostMilitech = 1
killCostNCPD = 6
killCostNetWatch = 1
killCostAnimals = 1
killCostMaelstrom = 0
killCostScavengers = 1
killCostSixthStreet = 1
killCostTygerClaws = 1
killCostValentinos = 1
killCostVoodooBoys = 1
killCostWraiths = 1
killCostCivilian = 10
killCostOther = 1

You may consider doing these:

1.Set every type of UsageCost in Wannabe Edgerunner to 1-3 (for the sake of gameplay balance, thou I didn't change this).
As quality multiplier applies to the UsageCost atm I'm writing, whenever you use an Epic Sandy (qualityMultiplierEpic = 2) with Usage cost = 7, you lose 14 Humanity points. TDO already has a Sandy Damage OverTime (DOT) system to do HP damage, I suppose an additional huge humanity loss isn't necessary. (One can only hope another modder to convert Sandy DOT into Damage To Humanity, as I'm not reading the code and syntax atm)

2.Go to Mod > TDO > NPC with Sandevistan/... in your in-game Menu, and lower every Dilution strength.
My current (untested) setting is
- NPC's Kerenzikov strength to 0% (Yes I'm turning Kerenzikov reaction off)
- NPC's Sandevistan MKI strength to 15%
- NPC's Sandevistan MKII strength to 25%
- NPC's Sandevistan MKIII strength to 75%

If I understand it right, at the moment I'm writing this, the NPC change in TDO forced enemies with a Sandevistan or Kerenzikov into time dilation as you enter yours. The issue was if you activate a normal (e.g., MKI/MKII class) Kerenzikov/Sandevistan, the NPCs will move so much faster than you and you're pretty much dead with the default setting. It's perhaps fine for players without these "hardcore" mods, but it's not really balanced nor realistic imo to have NPCs in the gang with a Sandy that can slow time by 75% or 95% (default *NPC's* Sandy MKI and MKII values).

So, the above values were set based on other Sandies with this mod default setting, so that using sandy isn't tha----t risky (I haven't been there yet, but I feel it's still very deadly if you activate your MKIII when facing certain boss (with NPC's Sandevistan MKIII strength)).

This is still a very cool mechanism to keep imo, so unless you absolutely can't play with it, try to change these settings to your liking.

3.(optional) Go to Mod > TDO > Sandevistan Damage over Time (DOT) in-game, and lower the DOT Minimum Health Limit to 0
Do this only if you want using strong Sandy to be deadly risky and dangerous (I haven't tried this yet, so I don't know how bad it will become, but I think it's probably fine).