Let's cut to the chase:
here's, imo, the mod loadorder you need if you want the best basis before modding further


Run Loot (MO2 has it built in) and Voila

You can then download my personal ini files for the Bug fixes mod, the SSE Engine Fixes mod, and the Scrambled Bugs mod. (also Powerofthree's Tweaks and Papyrus Tweaks NG for the Experimental performance options)
I have played dozens of hours with these so called "experimental" settings with nothing alarming happening other than the usual, you should give it a try!
Install this mod like you would any other mod, you just have to give it a higher priority than the other three mods/let it overwrite everything.

Note for the experimental INI file Version of this Mod:
To make sure it's working, you need to delete your existing ini files in your overwrite folder, otherwise this mod will be overwritten by yours and won't work. (Only an issue with the experimental INI version of this mod)
To do that, double click on overwrite at the very bottom of your load order in MO2

Then click "Open in Explorer" button, navigate through the skse > plugin folders, then delete the following :
- PapyrusTweaks.ini
- po3_Tweaks.ini
And voila

Additional notes:
— You may have noticed that I have SKSE and other root files like SSE Engine Fixes dlls installed as mods, that is because I am using Kezyma's Root Builder for Mod Organizer and I highly advise you to do the same in order to keep your root game files clean and safe, and keep everything organized and easy to find.
— This is a best of both worlds kind of setup (using SKSE/skyrim exes version 1.5.97 but using the latest skyrim update and Creation Club files), this is only possible thanks to Backported Extended ESL Support. This is imo the preferable way of doing things. You basically install 2 copies of skyrim, one updated skyrim AE via steam (keep it up to date), and another in 1.5.97 (there are guides on how to download that specific older "package" in steam, like this one).
Never touch the AE updated copy, and only mod the older 1.5.97 package you downloaded.
You then install the updated Creation Club and Update files from your AE updated game onto your SE copy of the game (as if they were a mod)
(that's what the "UPDATE & CC FILES 1170" in the picture above stands for) to do that, just create an empty mod inside MO2, then copy the data folder from your AE game onto that empty mod you just created.
— When using this best of both worlds setup, as a rule of thumb, all SKSE plugins need to be either marked NG (meaning all versions) or specifically made for 1.5.97. All other things like ESP files or textures/meshes it really doesnt matter since they would work in all cases, but preferably if it is an option, they need to be optimized for the Anniversary edition