No, "SEA" and "SEA+" are allowing to edit any NPC in-game, especially their "essential" status. My mod helps to change parameters of oblivion.ini to on/off death of essential NPCs. Of course you may change it by your own hands in wordpad but it's less conveniently than ingame changing with the mod.
Yeah an old school but quality mod "SM Essential Kills" handles this in a very no fuss no muss way. I've had it in my load order ever since its initial release. My only issue has been losing my temper and murdering people I really shouldn't lol.
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https://www.nexusmods.com/oblivion/mods/23580