The X-Files mod relies on Creation Kit as an overhaul to the Fallout 4 game.

In its beginning stages The X-Files mod focuses on replacement modifications. As development progresses, more stand-alone items will appear. 

Because this is an overhaul mod, it is highly recommended that you use Mod Organizer 2. That way you can switch from one overhaul to another, without interrupting your current or old game. See how this is done at Mod Organizer 2 configuring profiles tutorial at Fandom.

Vortex is not capable, nor has any plans yet revealed, to provide users with profile configurations. Vortex succumbs to the 254 plugin cap, rather than resolving the work around. This is what sets Mod Organizer 2 apart from all other mod installers.