Even I have described a lot of tools which help you with memory management and CTDs, it will happen that your starting game will freeze, especially when you use a lot of animations too.

It is not always easy to terminate the application via Task Manager, but Win10 has a nice feature to support several desktops, which helps in this situation.

So I created an additional desktop and always start the game there. Most of the time the few first starts are freezing.

Just hit CTRL-ALT-DEL and select the Task Manager. If it doesn't show up, hit WindowsKey+Tab and drag and drop the Task Manager window into your first desktop and select this desktop. Now you can terminate the Skyrim application and start again on your 'game' desktop.