"This lets you acquire the Orphanage key at the start of Sherry's section which makes you skip all of Chief Irons' chase sequence." Thank you, friend! The chase sequences and forced stealth were the worst part of RE2R (then again, forced stealth sections are the worst part about any video game that features them.)
To do this, you need to open the door in the parking lot in Leon's company. And in Claire's company, you need to remove the boards on the zombie's door when we move the water supply lever to extinguish the helicopter fire.
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