It's an occasional stutter that happen to the heavily script-laden player. The conversation "ends" and you regain control of your character but the HUD is still not showing (not even the targeting cursor) and quickkeys for things like Inventory and other pipboy screens don't work. You can go to console and back, you can (blindly) point yourself at objects and interact (again blindly as you're not seeing the prompts)...
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Is it possible to make use of it while playing with a controller?
Btw, the file folder is misnamed (SFSE) as is the file description.