Below is a script file for AutoHotkey, a free program. It is the result of two days trying to figure out how AutoHotkey works, and then trying to get the NUMPAD to work. This is not a good solution, as the "E" key seems to be hardwired and really irritating me, but I'm not a programmer, just a retired old guy trying to recover a $60 investment.
First you get AutoHotkey and install it properly. Then download this file and read through it and then read through the AutoHotkey material to understand what you are going to do with this file.
I use my own personal choices for remaps, I included the base code for the other game keys that I did not change, so review them, and once you get how it works, try it out on your own.
===============
Save this text to a simple text file, and then once you have AutoHotkey, you can use this text to create a keyboard remap for Lefties.
Once in game toggle NumPad if no movement occurs.
[file is now available as a zip file]
Everything Below this double line is the text for the .ahk file, so delete from the end of the line below back up to the word "Below."
THEN everything below the double double line is old stuff and just delete it. Might want to learn how AutoHotkey works.
===========================================
; LATEST VERSION 12/6/15
#SingleInstance Force
#MaxHotkeysPerInterval 99999
#IfWinActive ahk_class Fallout4
#Persistent
#UseHook
; program the keys this way - key you wish to press :: the key it emulates
; this restores the numpad (toggle numlock ingame to activate)
NumpadUp::w ; Forward (w)
NumpadClear::s ; Back (s)
NumpadLeft::a ; Strafe Left (a)
NumpadRight::d ; Strafe Right (d)
NumpadDiv::r ; Ready/Reload (r)
NumpadIns::Space ;jump
RShift::LShift ; Sprint
NumpadAdd::LControl ; Sneak
NumpadMult::LAlt ; Bash/Power Attack/Grenade ;could also use Down arrow.
; Favorites(f)
; Quick Inventory(i)
; Quick Data (j)
; Pause (Escape)
; Quick Stats (k)
; Quick Map (m)
; TOGGLE RUN (CapsLock)
; Quick Radio (o)
;  not recommended for change ****
;Right::e ; Activate (e) E key is hardwired in other menus as yet
; solution- is to change inside game [keypress]for e
; solution- I changed E in-game to Right arrow and then workshop menus will scroll properly
; Attack (LButton)
; Aim/Block (RButton)
; Pip-Boy (Tab)
; Toggle POV/Workshop (MButton3)
; Run (c)
; Quicksave (f6)
; Quickload (f7)
; q VATS  Q is also required in construction
; Auto-Move (x)
;
;Disabled keys. Use this if w/a/x still move player to disable key presses, for example to prevent both e and w from making you move forward.
;w::return
;a::return
;x::return
; modified iceray2000 for ********L E F T I E S *********  Embrace the NumPad!
; reset all keys to default in Settings.
; in-game toggle NumLock to activate keymaps, as this is to enable NumPad control use.
; work in progress. Any insights into further remapping for Lefties?
;updated 12/6/15
===============================================
===============================================
;==============================================
;*************OLD VERSION *******************
#SingleInstance Force
#MaxHotkeysPerInterval 99999
#IfWinActive ahk_class Fallout4
#Persistent
#UseHook
Pause::Suspend,Toggle

; program the keys this way - [key you wish to press] :: [the key it emulates] example - e::e

NumpadUp::w ; Forward (w)
NumpadClear::s ; Back (s)
NumpadLeft::a ; Strafe Left (a)
NumpadRight::d ; Strafe Right (d)
;Right::e ; Activate (e) this E key is hardwired as yet so it is commented out.
NumpadDiv::r ; Ready/Reload (r)
NumpadIns::Space ;jump
Left::LShift ; Sprint
v::q ; VATS (q)
NumpadAdd::LControl ; Sneak
RAlt::c ; Run (c)
q::x ; Auto-Move (x)
NumpadMult::LAlt ; Bash/Power Attack/Grenade
; Favorites(f)
; Quick Inventory(i)
; Quick Data (j)
; Pause (Escape)

; Quick Stats (k)
; Quick Map (m)
; Quick Radio (o)

;not recommended for change
; Attack (LButton)
; Aim/Block (RButton)
; Pip-Boy (Tab)
; Toggle POV/Workshop (MButton)
; Toggle Always Run (CapsLock)
; Quicksave (f6)
;Good luck, you are on your own after this, as I have no intention of supporting this further, and will only post improvements I make, or if I hear about ;LEFT-HANDED KEYBOARD TOTAL REMAPPING SOLUTIONS!
;====================================================
;Best of Luck - let's mod this puppy into the adult it was hoped to be.