I didn't try FO:NV but when I installed FO3 all I did is run it a 540p locked at 30 fps. I installed a mod to remove the blur effect, the unofficial patch and the integrated graphics bypass mod. All here on Nexus. The game ran just fine with the exception of Rivet City, the Riften of F03 performance hits. I may write up a guide but it might be too late for anyone to care since most people are probably playing on their gpdwin 2.
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Thank you
Would it be alright if you could make a guide for FO4 as well? That game's a bit more demanding and I get troubles playing it on my GPD.