I recommend using 4gb fallout mod if you're not already.
For DOF you can enable it in the "enbeffectprepass" file inside the "enbseries" folder.
OR I Perfer the DYNAVISION DOF ( http://www.nexusmods.com/newvegas/mods/51577/? )

Make sure that antialiasing, anisotropic filtering and water multisampling are disabled in the launcher, as opposed to HDR, which must be enabled.