When you press map menu hotkey ('M' by default), you will see all road signs on the map (original game behaviour).
When you activate the road sign itself, you will see only that road signs which you are allowed travel to.
You still can see activated road sign name (even if it does not have available destinations) so it can help you orientate yourself if you are using something like No GPS mod.
Possible routes
Vyzima -> Hanged Man's Tree (Velen)
Novigrad docks <-> Kaer Trolde Harbor (Skellige)
Vyzima <-> Nilfgaardian camp on south (Velen)
Vyzima <-> Woesong bridge (White Orchard)
Nilfgaardian camp on south (Velen) <-> Woesong bridge (White Orchard)
Brunwich (Hearts of Stone village) <-> Kaer Morhen
Hanged Man's Tree <-> Kaer Morhen
Cackler bridge (White Orchard) <-> Kaer Morhen
Plegmund's Bridge (Toussaint) <-> Vyzima
Plegmund's Bridge (Toussaint) <-> Novigrad nilf big camp on south
Possible conflicts
If you have FriendlyHUD installed, choose C + B (not B + C) for playerInput.ws conflict (check the second screenshot).