Seed:
By default, the seed is set to your character's name, but can be set freely (unless you are in VR, see [Known Issues] below). The seed will determine how things randomize; however, unlike other games/randomizers with a seed mechanic, having the same seed as someone else does not guarantee the randomization will be exactly the same. There are a lot of factors that can drastically change the randomization, such as what mods you have installed, what version they are, and their load order. Beyond that the base game already has some randomness as to what items you will find, which will then get randomized further by this mod.

Item/Spell Randomization:
The majority of what the randomizer does is change items and equipment in the game to other items and equipment. The Actors, Containers, and World Objects MCM submenus will allow you to fine-tune what types of items randomize, as well as influence what they randomize to. You can also completely disable randomization per-category if you desire.

Offsets:
While most of the settings should be fairly self-explanatory, offsets may not be as clear at first glance. Without any offsets enabled, all instances of an item should always randomize the same. You might have a seed where all Iron Daggers randomize into Wabbajacks, no matter where you find them or who yields them. But with offsets, it shifts that randomization based off the options you select. If you offset all items by an NPC's name, then only NPC's who share a name will have the same outfits (such as "Bandit" or "Whiterun Guard"). But if you choose to offset by an NPC's unique ID, then everyone will have a unique set of gear. Each category of randomization has different offset options, experiment with different settings to see what suits your playthrough best!

Factions:
Faction randomization does not randomize all factions in the game, as that generally just breaks the game in not very fun ways. Instead, this mod adds three factions to the game: Rock, Paper, and Scissors. These factions hate each other in a triangular faction. Rock hates Scissors, Scissors hates Paper, Paper hates Rock. You can control what percentage of NPCs get added to these factions. At 100%, all NPCs will be distributed evenly between the three, and chaos will ensue nearly everywhere. For an added challenge, you may add the player to one of these factions, for the chance of being attacked on sight by random NPCs. Note: Actor randomization needs to be enabled for Faction randomization to work. If you want the Factions to be randomized but not the items, you can disable item randomization in the Actors MCM submenu.

Experimental:
The Experimental menu will allow you to enable options that may not function as well as the rest of the randomizer. As of writing, the current experimental options work fine but slow down the randomizer considerably (which due to how Skyrim works, may slow down other mod scripts as well).

Skyrim's cart-ride intro is held together by duct tape and glue. Enabling the randomizer, even with all options disabled, will break the intro incredibly.

Workaround:
Wait until you've created your character to enable the randomizer.

While seemingly rare, and likely dependent on what mods you have installed, sometimes the game doesn't like certain items being in certain inventories.

Workaround:
Follow the instructions above to temporarily disable the randomizer, until you pass the point that the game was crashing.
Changing the seed of the randomizer instead may be preferable if the crashing happens often.

The evidence chests in jails act as a quest chest, which the randomizer just adds items to, instead of replacing the items in it, meaning when you exit the jail you will end up with twice as many items. There is a check in place meant to prevent this, but for some reason it does not work.

Sometimes when you enter a player home that has a customizable bookshelf, you get a message on your screen that says something along the lines of "Only books can be placed on this shelf." This is due to the randomizer trying to randomize the bookshelf.

Workaround:
The issue can be alleviated by avoiding use of these bookshelves. Pick up any books on the shelf and drop them from your inventory. Placing them manually on the shelf without the use of the bookshelf inventory should be fine.

A potential fix is in the works and may be available in a future version of the randomizer.

This is an unfortunate side effect of Papyrus being slow, Skyrim pausing most code execution while in a menu, shops not refreshing stock until you open them, and shop menus not updating automatically. It's a sad mess caused by Bethesda. The usual behavior you will see is a shop closing immediately upon entering it, then closing after a while of having it open a second time. After this the shop shouldn't close on you until they've restocked.

Workaround:
The auto-closing shop functionality can be disabled under the "Main" MCM menu. This will mean you are more likely to have an un-randomized shop until you buy something.

I have not yet tested this, but using the Skyrim Souls mod may speed up shop randomization due to the menu being unpaused.

Skyrim has a concept of items that are "non-playable", which are items that can't be seen or interacted with in an inventory by the player. There usually should be no method of obtaining these items, but rarely the randomizer can spawn them in the world, which can be picked up by the player. Once picked up, because they do not show up in the inventory, they cannot be dropped and may add "invisible" carry weight to the player.

Workaround:
The best workaround at the moment is to avoid these items altogether. If you pick one up and realize it's non-playable, reload a previous save, take note of what the item is, and don't pick it up in the future. It may be best in this case to change the randomizer seed as well.

I have not been able to test this due to the rarity of one of these items showing up, but you may be able to get this out of your inventory by purposefully going to jail, breaking out of jail (don't serve time), and stealing your items back from the evidence chest. In theory this will put the invisible item in the evidence chest, but you won't be able to take it out.

This is an issue that seems to have some bizarre connection to loading into the game with the default character, then trying to navigate to one of the MCM submenus. Most of MCM stops responding until a game restart. This normally wouldn't be a problem, as the only way to trigger that is by using a COC command from the main menu, but it would appear that the VR version's main menu loads in with the default character in a similar way.

Workaround:

1. Close Skyrim
2. Reopen Skyrim
3. Load a previously-unmodded save (a save you made without any mods enabled)
4. Ensure you can open the "Main" ToxiRandomizer MCM submenu (don't enable the randomizer)
5. Exit to Main menu
6. Create a new character

That new character should be able to use the MCM menu. If you have an existing save you want to use the randomizer on but MCM freezes on that character, I'm not sure there's anything that can be done. Skyrim is cursed.

Something about SkyUI VR makes that one particular option invisible and uninteractable. The randomizer will still work, the seed will be set to the name of your character.