Lonely Skyrim is a mod that removes all NPCs from the game. However there are different versions available.
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Skyrim is a lovely place, where we can go to to escape reality. We can get caught up in the politics and struggles of another world or just hunt as a huntsman. And the pretty much infinite mods allow us to customize our game more. But what would happen if all the creatures and NPCs just up and vanished. Never to be seen again.
This mod has three versions. No Creatures or NPCs, pretty self explanatory. No NPCs, removes all NPCs but keeps creatures in. Or No Enemies, which removes all NPCs and all violent creatures in the game. What will you do without NPCs?
This does not remove any NPCs from other mods or from the official DLC. It's recommended to use an alternate start mod as the opening won't work if you do the vanilla Skyrim opening. All screenshots are taken at 9-10AM in Skyrim.