Instructions:
Copy and paste both files into your Skyrim/Data folder.

This mod does not edit any major existing records.
It should not matter where it is located in your load order.
But I have heard of issues in regards to werewolf and vampire mods and their respective perk menus.
I don't know why MCM menus may cause bugs with werewolf/vampire menus but it can be cirumvented by putting this near the top of your load order

If you have any mods that edit settings changed by SkyTweak,
SkyTweak will always override those mods regardless of load order.

Requirements:
SkyUI Version 3.4 or higher
SKSE Version 1.6.13 or higher