UPDATE : 

Changing your pixel size under dosfx to define PIXELSIZE 3.53 will give a fair balance between pixels and being able to read text, and turn off any anti aliasing and reduce rendering quality to 50% at 1920X1080.



First off, this is a guide! to transform your game into a Noir pixelated horror game, bringing back vibe of the olden days of PS1/PS2 but stylized.

Leave questions or concerns in the posts sections, i will not be bug solving, just giving advice.

Step one :

Go to this link : https://www.mediafire.com/folder/8ar1jhh1809cl/ReShade_Repository#9ckrmgp4813fy this is BigEX20's archive of older reshade versions.

Download Reshade 1.1.0 with framework

STEP TWO:

Navigate to your download of reshade 1.1.0 with framework and open the archive with the one of the following Winzip/WinRaR or 7zip

STEP THREE :

Go to your steam library and right click resident evil 2 then go to local files and browse local files, within this main directory you will see RE2.EXE and various other files, If so drag drop the contents of the previous step into the folder with the RE2.EXE, Now find the reshade64.dll and rename the file by right clicking it and navigating to rename, Rename to the file to dxgi.dll

STEP FOUR : You will now need to navigate to the reshade folder within the main directory and find the customFX.cfg and open it with notepad/wordpad or evq.

STEP FIVE : While you have the customFX.cfg open, press CRTL + F together. Now enter within the search type Sincity and you will be brought to the line of code that looks like this 

////-----------//
///**SINCITY**///
//-----------////
#define USE_SINCITY 0 //[ColorCorrection] //-Sin City: Effect from the movie "Sin City" - everything else than red is grey.

Turn the ZERO into a 1

STEP SIX : 

Reopen search with CRTL + F and then enter DOSFX, you should be brought to a line of code that looks like this 

Either copy and paste this into your cfg file or copy it manually by typing it in.

DONT FORGET TO PRESS SAVE OR CRTL + S BEFORE YOU EXIT NOTEPAD/WORDPAD

////---------//
///**DOSFX**///
//---------////
#define USE_DOSFX 1 //[DOSFX] //-It simulates how most of the old games looks like by degrading colors. Stunning feeling if you are an old gamer
//>DOSFX Settings<\\
#define PIXELSIZE 3.66 //[0.0:999.666] //
#define ENABLE_SCREENSIZE 0 //[0:1] //
#define DOSColorsCount 16.0001 //[0.0000:32.0001] //-
#define DOSCOLOR 0 //[0:1] //
#define ENABLE_POSTCURVE 1 //[0:1] //
#define POSTCURVE 0.375 //[0.0:2.0] //
#define ENABLE_AGD 1 //[0:1] //
#define DoSgammaValue 2.3 //[1.0:5.0] //
#define DOSScreenSize float2(320.0,240.0) //[undef] //-QQVGA=160.0, 120.0 ; HQVGA =240.0, 160.0 ; QVGA = 320.0, 240.0 ; another resolutions
#define Dos_ToggleKey RFX_ToggleKey //[undef] //

Kudos to Corsair!