Unsubstantiated rumours place Fallout 4 in Boston, Massachusetts
Bethesda has (amazingly) refused to comment on the speculation despite the convincing disclaimer at the beginning of the anonymous tipster's post.
Massachusetts was referenced in Fallout 3 as "the Commonwealth", home of "the Institute", likely to be descended from the Massachusetts Institute of Technology. The Institute is reknowed as a centre of highly advanced scientific and technological discovery, while the rest of the Commonwealth is described as a violent and lawless place.
The player interacts in Fallout 3 with a member of the Institute. He is pursuing a runaway android that was built in and ran away from the Institute, with the help of an organisation called the Railroad (because they don't have anything better to do in a post-apocalyptic wasteland other than to help escaping androids). You can find out more about the Commonwealth and the Institute at the Vault.
The rumours are currently unsubstantiated, but Fallout 3/New Vegas Nexus will bring you more news as it becomes available.
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A moderator has closed this comment topic for the time beingInteresting for Boston but I hope we don't have to wait two more years for it.
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I think Boston is good bet though. It has the institute, cool tech, androids, the railroad, and an urban environment which everybody seemed to love about FO3
change to compete with XBOX. With SKYRIM mem. issue on PS3, FALLOUT4 would need next gen. console.
But I also liked FNVegas because I have seen alot of Vegas and the places near Vegas like Zion National Park. So I would have to say if the new Boston game sticks to detail of locations, etc. people will say hey I know that place and connect with it like Wash,DC and all the museums. But don't for get about Three Dog the radio jock - he made it enjoyable listening to it with updated heroics by you the player. I hope you can pick up Three Dog in Boston..