Five characters from the start of the game are turned into super powerful bosses(mostly health wise),and are all dressed weirdly and deformed.
They are quite hard to fight and fighting them is a campaign itself.
It took me 2 and 1/2 hours to kill them all,and that's just with console commands...

I'd highly advise you using the command "advlevel" in the console until you get to level 30 or so before fighting them,or if you want a challenge fight them at a low level.(Courier's Stash is reccomended though.)

Here's a list of the bosses you should fight in order.
1.Dorche Meeshelle(Doc Mitchell)
2.Isi Peet(Easy Peet)
3.Khete(Chet)
4.Doge(Cheyenne)
5.Sonnie Smilettes(Sunny Smiles)

Here are their stats.
All bosses have MAXed out special and are level 100 btw.

Dorche Meeshelle:
9,215 HP
0 DT
Carrying pre-war bonnet
Has "Figaro" as a weapon (33.2 DPS Mnt. Cnd.)

Isi Peet:
16,140 HP
0 DT
Carrying tenpenny's suit and pre-war cap
Has "Knock-Knock" (118.8 DPS Mnt. Cnd.,Large weapon with large range,attacks knock you back and have a high cripple chance,but after attacking with it they cannot move for a second or so.)

Khete:
23,000 HP
0 DT
Carrying....prostitute outfit
Has "Paladin Toaster" (67.1 DPS Mnt. Cnd.,Temporarily Stuns you,blinds you,and knocks you back on hit,unarmed weapon,with 41 crit damage.)

Doge:
450 HP
5 DT
Alerts Sonnie when attacked.
Drops "Pushy" to help combat Sonnie.

Sonnie Smilettes:
31,540 HP
Carrying prostitute outfit...again...
Has "Deathclaw Gauntlet" (32.6 DPS Mnt. Cnd.,5x crit chance,30 crit damage,and pierces all armor,completely negating all DT,also unarmed,and has a high item health of 600 HP.)
Final Boss of the mod

Soon more bosses will be added,in Primm,to be exact.