I have been suffering major stuttering when playing the game (especially in some specific areas, when turning around, after every quicksave and fast travel) even with all the usual performance improving mods. These are the config ini files I am using now which fixed all of the performane issues I was
having.

Saved config visual settings are:
1920x1200 resolution (change in FalloutPerfs.ini to your native res)
Ultra settings with no Water Displacement. AA and vsync
95 FOV
NVSR FPS limit set to 60

My specs:
i7 4770k 4.2GHz
GTX 970 4GB
32GB DDR3
1TB SSD
Win7 Ultimate 64bit

The archive includes:

1. Configs from Steam NV folder:
- Fallout_default.ini
- enblocal.ini (I am running the default ENHANCED SHADERS mod)
- Data > NVSE > Plugins > sr_New_Vegas_Stutter_Remover.ini

2. Configs from My Documents NV folder:
- Fallout.ini
- FalloutPerfs.ini

Just replace your current ini files with mine (backup just in case), and change the resolution if needed.