During installation you'l be able to toggle the following changes:

• Deadly Bosses
• Limbs take Less Damage
• Nerfed Ballistic Weave
• Nerfed Crafting
• Nerfed Workshop
• No Rest Bonus
• Nerfed Weapon Perks
• Acid Scrap
• Higher Prices
• Nerfed Furious
  

DEADLY BOSSES
Reduce the damage taken by bosses by 50%
Bosses are:
-Deathclaw
-Behemoth
-Sentry Bot
-Glowing One (ghoul)
-Mirelurk Queen

Affect any level, type or tier of creatures. Works on any difficulty level.


LIMBS TAKE LESS DAMAGE
Makes a target take less damage if hit on a limb.

- It makes harder to kill someone by shooting their legs
- It's only applied to humanoid races: Human, Super Mutant, Ghoul, Synth.
- It has nothing to do with limb damage. (It's not a change to "Limb Damage" function. You'll still be able to cripple limbs the same way).
- The damage caused on limbs is reduced by 50%.
- Affect both Player and NPCs.


NERFED BALLISTIC WEAVE
Reduce the effectiveness of Ballistic Weave and remove the Railroad Quest condition to apply them.
The effectiveness of ballistic weave is reduced by 50%.

With the perk Armorer rank 4 you could apply 120 damage AND energy resistance to your base cloth, while it takes 5 ranks on Toughness / Refractor to grant you +50 damage OR energy resistance. Clearly unbalanced. Still unbalanced, that's why I recommend my mod: Creative Perks


NERFED CRAFTING
Make the crafting of drugs, chems and grenades a bit harder by increasing the required ingredients.

Spoiler:  

Show

[add] [removed] [vanilla]

Psycho
Hubflower x 2 
Stimpak x 1 + 1
Acid x 1 + 1

Jet
Fertilizer x 2 + 1
Plastic x 1
Brain Fungus x 2
Stimpak x 1

Mentats
Abraxo cleaner
Brain fungus x 2 - 1
Lead x 1 
Glowing Fungus x 2
Acid x 2

Stimpak
Antiseptic x 2 + 2
Blood pack x 1 (x 2 on Survival)
Bloodleaf x 1
Steel x 1

Vegetable Starch
Corn x 3
Mutfruit x 3
Tato x 3
Purified water x 1 + 2 
Slit Bean x 1

Frag Grenade
Adhesive x 3
Aluminium x 2 + 1
Fertilizer x 2 + 1
Oil x 3
Lead x 2
Spring  x1

Plasma Grenade
Adhesive x 4
Aluminum x 4
Circuitry x 2 + 2
Nuclear material x 3 +1
Spring x 1

Pulse Grenade
Adhesive x 4
Aluminum x 3
Circuitry x 1 + 2
Nuclear material x 2 + 1
Spring x 1

Refreshing beverage
Antiseptic x 3 + 7
Blood pack x 1
Purified Water x 2 + 5
Radaway x 2 + 3
Stimpak x 1 + 2
Carrot Flower x 2 (Surival only)



NERFED WORKSHOP
Workshop Changes:
-Workshop now produces Dirty Water instead of Pure Water
-Workshop now produces less Food, Water and Fertilizer (10% down from 75%).

NO REST BONUS
Remove the SPECIAL bonuses from Well Rested and Lover's Embrace. The XP bonus is not removed.


NERFED WEAPON PERKS
Each perk rank will increase weapon damage by 15%, 10 or 5% (Options available during installation).

Affected perks:
-Heavy Gunner
-Rifleman
-Gunslinger
-Commando


ACID SCRAP
Add acid to some junk. Acid is a very rare material in vanilla game and almost without purpose, but if you use any ammo crafting system, you know how bad it's to farm acid from scraps, and you end up only getting the acid you need from shipments, which is kinda boring.
Changes the following Misc Items:

• Abraxo Cleaner Industrial/Undamaged now contains much more Acid.
• Turpentine now contains Acid.
• Rat Poison now contains Acid.
• Empty Coolant now contains Acid.
• Radscorpion sting now contains Acid.
• Empty Blood sac now contains Acid.
• Makeshift Battery now contains 6 acid / 6 lead.
• Fertilizer Bag now contains 2 Acid / 6 Fertilizer.
• Bag of Cement now contains 20 cement.
  

HIGHER PRICES
-Increase the price of Components Shipments by ~ 50%.
-Increase the Price of Stimpak by 100%.

NERFED FURIOUS

Reduce the effectiveness of the Legendary Weapon affix: Furious
Vanilla: Damage increased by 15% after each consecutive hit on the same target.
Modded: Damage increased by 7% after each consecutive hit on the same target.

The Vanilla Furious when applied to a automatic weapon can be way too overpower, after 10 shots you'll have a 150% damage increased, considering you're not even on half of your clip.


Recommended Mod:
Fallout 4 Loot Overhaul

My other Mods:
Creative Perks
Tali's Presets