Compilation of various tweaks to adjust the base game. Just use the ESPs that interest you. Only Fallout4.esm required (no DLCs, unless indicated).
Made with the Construction Kit. Manual mod installation only.

FIRST AID
Stimpacks are very common, this tweak makes Stimpacks much rarer in First Aid boxes and Mirrors. It also introduces more "First Aid" themed junk for more immersion. This esp only changes a few levelled lists and a couple of containers.
Stimpacks on NPCs and placed in the world have not been changed.

This will make the game slightly more difficult, making food and trading will be more required

V1.1 Changes - Added Antiseptic to lists

CLUTTER
Adds more junk/components to Raiders and Feral Ghouls (same list as the workshop scavenging rules), plus allows Raider Boss chests to have more loot generated (Beth actually included more items to spawn in the chests then was actually allowed). The idea is that you are not the only one out scavenging "useful" building materials. (in the case of Ghouls, who knows what is going through what remains of their brains).
Adds weight to junk/misc items that were weightless (like Pre War Money)
Adds scrapping materials to junk that couldn't be scrapped (such as folders)
Tables/Filing cabinets have increased chance of having "Office" themed junk (instead of nearly always being empty)

This has no change on the adventuring part of the game, but will make the building part slightly easier

V1.1 Changes - tweaks to the raider lists so they are not so full of loot


FOOD
All common craftable food no longer is rad free. Makes no sense that cooking radiated raw materials removes the radiation. Instead, the cooked meal only has 25% of the rads of the raw materials. Makes RadX and the perk to stop radiation from food much more important. Eating food you find is just as good as cooking your own food (at the start).

This will make the game slightly more difficult

FOOD (SLOW) - New in V1.1
Same as Food, but regen times extended to up to 40 seconds, with lower amount healed per second. Food provides a gradual heal so not a substitute for a stimpack during combat.

IMPORTANT: Use Food or Food (Slow), not both


CHEMS - New in V1.1
Makes chems less common in levelled lists (especially on raiders) by adding in poor quality chems. These chems give lower bonuses, and are more addictive. These chems are not craftable.

This makes the game slightly difficult by just reducing the cap value from your looting raids.

VENDORS (requires Wasteland Workshop DLC) - New in V1.1
Start of an overhaul of Vendors to make them more unique (in terms of inventory), less player centric and provide a greater requirement to actually trade with them.

The initial release lowers their base starting caps, removes shipments from most vendors and tweaks various lists. Most vendors will have a quantity of wood, steel and concrete components, plus components matching any shipments that they used to have.
Vendors selling ammo will no longer be stocking every ammo type (based on your level), but random ammo. You'll have to wait for their inventory to restock to see if they get the ammo you need - they are no longer player centric.
Vendors selling Grenades have a greater stock of Molotov's over other grenades.

This will make settlement building even more of a scavenging hunt and more difficult, and may make gameplay a little more difficult

RAIDERS - New in V1.2
Adjusts raiders equipment and loot lists, they are more likely to have pipe guns, melee weapons and basic armour, with their leaders having the better gear