Since mod authors face CTD reports from users frequently i decided to place some notes about possible reasons and fixes for game CTDs. Although the list below is by no means complete, it covers most common scenarios:

1. Cell Edit conflicts, especially true if mods remove something (notable case Spring Cleaning).
2. Saves corrupted by some other Cell editing mods (including settlement mods).
3. Navmesh/AI path finding problems of the game engine. 
4. System overtaxing/fallout 4 engine memory leak. 
5. Unofficial Fallout 4 patch has been confirmed to cause crashes and is incompatible with this mod!

I don't know if people are aware but currently where are problems with compatibility between all mods that edit Cells and those can not be addressed by any form of merged patch or anything like that, only Bethesda can fix that. Main reason is simple - you can not place anything into the worldspace without attaching copy of parent cell to the ESP file. Since master load orders from which Cells are copied are different from one author to another, game ends up with many different versions of the same cell, if several mods edit any particular game cell. Normally it's just a simple case of winning override which mod's record will be used, that is not the case with Cell editing, since game used special flags/timestamps to determine one that should be loaded. Any present Cell edit conflict ensures gamma of consequences you are surely familiar with, namely: screw up of precomputed visibility (previs), precombined meshes, Cell resets, container resets, spring bug and ultimately - CTDs in some cases. This general problem is well known and was extensively discussed at the beth.net forums (for example, here https://community.bethesda.net/thread/13241?)

The only real way to resolve such kind of conflict is to use FO4Edit to resolve all those by hand, and as you may guess that may be impossible to do if many cells are conflicting (entire game region for example). Another possibility is to take a close look at your load order and try to eliminate some other mods that edit cells, those include lighting and fog mods, new interior mods, settlement mods etc. Remove them one by one until you find the sucker that cause problems. Sometimes moving WOTC in the load order to near to start or near the end of list helps, but that is not the general case.

Some mods edit Cells in particuarly bad way, one particularly notable example is Spring Cleaning mod. In attempt to mitigate cell reset bug SC author made some nasty edits, what cause the rain of compatibility and CTD trouble. To make matters worse, it had been found that SC edited data still persists within the save even after the master mod removal, so deinstall will not help. In case of such corrupted save only solution is to load save that was made before Spring Cleaning (or stuff like it) was ever installed, or to remove it for good and start the new game.

Another possible reason for crashes are AI path finding problems, those were a scourge of Bethesda games for a long time, Fallout3 suffered greatly from this issue. In some cases game seems to be unable to resolve pathing problem and on certain conditions (probably some internal pathing stack overflow) game just CTD immediately. Since my mod forces NPCs to do a lot of pathing, that problem becomes amplified, and it causes CTD sometimes, when no notable conflicts or any other reasons are present. Where are some Vertical spawns (spawns on the rooftops) and Highway spawns my co-author Coreyhooe placed, that can cause such kind of trouble, since lazy Beth had not paid attention to place any navmesh on most roofs and highways. That can be source of CTD rain, so i recommend to set the area density for Vertical (and optionally Highway spawns as well) to zero using mod config menu, that will effectively disable them possibly leading to the fixing of the CTD trouble.

At the end of the list we have a general stability problem, that means that game will CTD a lot regardless of anything else if you are overtaxing your system with number of mods or with resource heavy mods. I evidently seen many of such CTDs, for example one can easily replicate it by using Loose cannon preset of my mod and ride by vertibird to the BOS airship during BOS or Rairoad quests. Disabling spawns prior ride temporarily solves that problem, but fundamentally nothing can be done with that on modder side. In case i mentioned, too many spawns/pathing activations caused by this fast traveling in resource heavy areas caused engine to be overwhelmed and crash. For the obvious reasons that kind of CTD problems are commonly localized to the city areas since game performance is awful at those from the time of the first game release.

I hope that my tips will help those who get frequent CTD issue, so you can join our ranks and fully enjoy the scope of the mod.