If like me, you can't be bothered to micro manage your weight all the time so you use a bigger inventory cheat mod like the AWOP 4D storage device, you'll inevitably end up with huge inventory... So it's best to every now and then delete all of your unwanted items to prevent crashing and lag from the engine not being able to handle so many items.

For example, whenever a quest strips all of your gear, and you have an enormous inventory, IT WILL CRASH...
So it's best to only stick with what you need and not hoard all of those laser pistols you'll never use <_<

First save your game because moving many items tends to cause CTDs, then transfer all your unwanted items to any empty container, spamming enter on unstacked items is fast but for stacked items, there's a mod that when you shift click a stack of items it moves them all without prompting for how many to move but I don't recall what mod adds this, might be stewie tweaks not sure. Anyways you might want to make a quicksave in between every few hundred items you move in case of CTDs so you don't have to start all over.

Once you've managed your inventory, make another save or quicksave then open the console command with ~ click on the container you transfered all your junk to and use the removeallitems command on the container to delete all the junk in the container. You might CTD the first time of doing this so load back up your quicksave and try again, this time hopefully it deletes the junk without crashing, if not you'll have to reduce the amount of items in the container, quick save and try again.

You should now have a snapier inventory.

IMO This is better than exlusively getting rid of stuff by trading since although you do get caps, it's a slower process having to travel around looking for traders, and hoarding everything in multiple containers just delays the problem.