See below for significant new items and a general idea where you can find them. I'm being cautious about power creep and almost all of the new items in Act 1 are "green" (uncommon) rarity, and "blue" (rare) for Act 2 items. They are intended to be situationally useful and not necessarily just "better" versions of existing items.


Tutorial

• Basic White Item Kit - Nautiloid
  

• Wisdom Boon* - Looted from Elite Arcanist in starting area of Act 1
  

• Superior Githyanki Boots* - Looted from 'Celes' outside of Withers' chapel
• Superior Githyanki Bracers* - Cellar in Blighted Village
• Featherlight Boots - Cellar in Blighted Village
• Gloves of Flint and Steel - Cellar in Blighted Village
• Scroll of Artistry of War - Cellar in Blighted Village
• Ceremonial Splint Armor* - Crypt room with Withers
• Constitution Boon* - Wilderness, near Grove entrance
• Illmater's Aid Amulet and Hag's Ring - Between Grove and Blighted Village
• Circlet of Protection* - Blighted Village
• King's Blade +1* - Blighted Village
• Blackplume Helm* - Outside of Blighted Village
• Melf's Crossbow* - Swamp (0.65)
• Infernal Warhammer - Swamp (0.66)
• Glaive +1 - Risen Road
• Rapier +1 - Risen Road
• Pike +1 - Outside of Waukeen's Rest
• Tough Sunrises - Outside of Waukeen's Rest
• Mind Tax Amulet - Outside of Waukeen's Rest
• Dexterity Boon* - Looted from Firion in Zhent Hideout (0.5)
• Warhammer of Dexterity* - Outside of Goblin Camp
• Shortbow +1 - Outside of Goblin Camp (0.5)
• Strength Boon* - Outside of Goblin Camp (0.5)
• A Sparking Promise - Goblin Camp
• Boots of Apparent Death - Goblin Camp
• Shimmering Crossbow* - Inner Sanctum (0.65)
• Divinity Amulet* - Inner Sanctum (0.65)
• Studded Leather +1 - Grymforge
• Intelligence Boon* - Grymforge
• Shield +1 - Looted from Caeylnn, a "Paladin of Tyr"
• Arduous Flame Blade - Cellar Room Underneath "Paladins of Tyr"
• Dauntless Amulet - Outside Creche
• Deadly Channeller Gloves - Outside Creche
• War Pick +2 - Path to Creche
• Ringmail +2 - Path to Creche
• Githyanki Half Plate +1* - Creche Training Room
• Gloves of the Templar* - Creche main room
• Boots of the Templar* - Creche main room
  

• Dexterity Boon* - Near Meazel's House (0.5)
• Scimitar +2 - Near Meazel's House (0.5)
• Blood Bound Blade - Near Vine Blights (0.66)
• Kanithar's Longsword* - Mason's Guild (0.5)
• Shortbow +2 - Mason's Guild (0.5)
• Strength Boon* - Mason's Guild (0.5)
• Absolute's Smite - Looted from Alexei Silvershield in Mason's Guild (0.5)
• Greatsword +2 - Looted from Alexei Silvershield in Mason's Guild (0.5)
• Longshadow Battleaxe* - Looted from Arthur Longshadow outside of House of Healing (0.5)
• Longshadow Helmet* - Looted from Arthur Longshadow outside of House of Healing (0.5)
• Ascendant Quarterstaff* - House of Healing balcony (0.5)
• Robe +2 - Looted from Sergor Lightfoot under Tollhouse (0.5)
• Myrkulite Scourge - Looted from Sergor Lightfoot under Tollhouse (0.5)
• Shar's Sting - Under Tollhouse (0.66)
• Magical Hand Crossbow - Looted from Stedd Stormwind (0.66)
• Executioner Sword - Looted from Katerina Silverspring (0.66)
• Pike of the Vanguard* - Waning Moon (0.5)
• Wisdom Boon* - Waning Moon (0.5)
• Morningstar +3 - Looted from Glar Stormgazer in Waning Moon (0.5)
• Spear +2 - Looted from Fallen Champion in Morgue (0.5)
• Charisma Boon* - Looted from Fallen Champion in Morgue (0.5)
• Quarterstaff +2 - Gauntlet of Shar (0.5)
• Morningstar +2 - Gauntlet of Shar (0.5)
• Sandthief's Ring - Gauntlet of Shar, near Balthazar (0.5)
• Shadowstep Boots - Gauntlet of Shar, near Balthazar (0.5)
• Dark Justiciar Gauntlets - Gauntlet of Shar, near Entrance (0.5)
• Half Plate +2 - Looted from Marcon Strongheart inTadpoling Center (0.5)
• Intelligence Boon* - Looted from Marcon Strongheart in Tadpoling Center (0.5)
• Fine Steel Glaive* - Tadpoling Center (0.5)
• Constitution Boon* - Looted from Avatar of Loss in Shar's Shrine (0.5)
• Maul +3 - Looted from Avatar of Loss in Shar's Shrine (0.5)
  

• Strength Boon* - Rivington Well (0.65)
• Tempest's Flail* - Rivington Well (0.65)
• Constitution Boon* - Rivington Near Windmill (0.65)
• Nightsong's Armor - Rivington Near Windmill (0.65)
• Dexterity Boon* - Rivington Near River (0.65)
• Scarab of Protection - Rivington Near River (0.65)
• Avernus Morningstar* - Devil's Fee Cellar (0.65)
• Blade of Lathander* - Looted from Valafar Demonshade in Hag Survivors' Cellar (0.65)
• Intelligence Boon* - Umberlee Vault (0.65)
• Charisma Boon* - Blood Merchant's Lab (0.65)
• Enchanted Psionic Half Plate* - Blood Merchant's Lab (0.65)
• Strength Boon* - Cazador's Attic (0.65)
• The Impaler - Cazador's Dungeon (0.66)