Each player, after selecting one of the heroes, plays a deck of 40 cards against the villain and environment decks, which "play themselves",
requiring the players to put the top card of the appropriate deck into
play on the villain and environment turns. On each player's turn, they
may play a card from their hand, use a power printed on one of their
cards in play, and draw a card from their deck. Each round starts with
the villain turn, continues clockwise around the table, then concludes
with the environment turn. Each villain has various advantages, such as
starting with certain cards in play, as specified by the villain
character card. Play continues until the heroes reduce the villain to 0
or fewer HP, or until the villain defeats the heroes, either via a win
condition or by reducing all the heroes to 0 or fewer HP.

Large Expansions:
Sentinels of the Multiverse: Rook City (includes 2 additional heroes, 4 additional villains, and 2 additional environments)
Sentinels of the Multiverse: Infernal Relics (includes 2 additional heroes, 4 additional villains, and 2 additional environments)
(Note: The 2nd Edition printings the first two expansions were combined into one box with all 4 heroes, 8 villains, and 4 environments, listed as Sentinels of the Multiverse: Rook City & Infernal Relics Expansion)
Sentinels of the Multiverse: Shattered Timelines (includes 2 additional heroes, 4 additional villains, and 2 additional environments)
Sentinels of the Multiverse: Vengeance (includes 5 additional heroes, 5 additional villains (which are played together), and 2 additional environments)
Sentinels of the Multiverse: Wrath of the Cosmos (includes 2 additional heroes, 4 additional villains, and 2 additional environments)
Sentinels of the Multiverse: Villains of the Multiverse (includes 10 villains in the Vengeance expansion style of multi villain play, and 4 additional environments)

Mini Expansions:
Each mini expansion includes 1 additional deck.
Sentinels of the Multiverse: Unity Hero Character
Sentinels of the Multiverse: The Scholar Hero Character
Sentinels of the Multiverse: Ambuscade Villain Character
Sentinels of the Multiverse: Miss Information Villain Character
Sentinels of the Multiverse: Wager Master Villain Mini-Expansion
Sentinels of the Multiverse: Silver Gulch, 1883 Environment
Sentinels of the Multiverse: The Final Wasteland Environment
Sentinels of the Multiverse: Omnitron IV Environment
Sentinels of the Multiverse: Guise Hero Mini-Expansion

Promotional Cards:
Each promo card provides an alternate character card (2 for villains) to be played with the associated character deck found in the core game or expansions. Promo Packs are a set of these cards distributed together.
Sentinels of the Multiverse: Young Legacy Promo Card
Sentinels of the Multiverse: Rook City – The Wraith Promo Card
Sentinels of the Multiverse: Mad Bomber Blade Villain Promo Card
Sentinels of the Multiverse: Cosmic Omnitron Villain Promo Card
Sentinels of the Multiverse: Ra, Horus of Two Horizons Promo Card
Sentinels of the Multiverse: Redeemer Fanatic Promo Card
Sentinels of the Multiverse: Dark Visionary Promo Card
Sentinels of the Multiverse: Freedom Six Promo Pack (Contains 6 hero promos)
Sentinels of the Multiverse: The Eternal Haka Promo Card
Sentinels of the Multiverse: Dark Watch Promo Pack (Contains 4 hero promos and 2 villain promos)
Sentinels of the Multiverse: America's Greatest Legacy Promo Card
Sentinels of the Multiverse: G.I. Bunker Promo Card
Sentinels of the Multiverse: The Prime Wardens Promo Pack (Contains 5 hero promos)
Sentinels of the Multiverse: The Super Scientific Tachyon Promo Card
Sentinels of the Multiverse: KNYFE Rogue Agent Promo Card
Sentinels of the Multiverse: Kvothe Six-String Argent Adept Promo Card

Accessories:
Sentinels of the Multiverse: Villain Oversized Cards