I am going to show you on how to fix Nexus Mod Manger with Anti Virus to stop the crashing when uninstalling mods.

Some Users have reported the issue and the anti virus is causing this issue so i hope the tutorial gets the error away.

You May also have to add the nexus Mod Manager to the Exception list as well including all subfolders if you are still crashing when adding the game folder to the exception list.

The default installation for the Nexus Mod Manger is C:\Games\Nexus Mod Manager

there are 4 tutorials Now

How to fix with Trend Micro
How to Fix With AVG 2013
How to fix with Windows Defender
How To Fix Nexus Mod Manager with Malwarebytes

Credits:
Nexus team for the Nexus Mod manager
Bethesda for their hard work on Skyrim
Kudos to them