I am using Boris Vorontsov's latest ENB for Skyrim (0.157).
I added alot of effects including skylighting, edge AA, Ambient Occlusion, and DOF.
/////Note////
If you are using any Parallax mods, go to your enbseries ini and set true for fixparallaxbugs.

I also disabled ComplexAmbientOcclusion and ComplexIndirectLighting for better performance and minimal loss in quality. I also decreased the amount of darkness in shadows so nights and dungeons are a lot easier to play in.

//////Recommended Mods/////
Please install Climates of Tamriel v3.1 and Realistic Lighting Overhaul excluding integrated weathers for the best quality. I suggest using 2k textures and Static mesh improvement mod.

//////SkyrimPrefs.ini////////
bTreesReceiveShadows=1
bDrawLandShadows=1
bShadowsOnGrass=1
bFloatPointRenderTarget=1

///////My Specs////////

Gtx 650 ti overclocked
I5 2400
8gb ram
320 gb hard drive

38 fps average