*UPDATE for DEF_UI v1.1.0*

This setting for DEF_UI is simple, cleaned up and immersive. You should consider install this mod as well: No cash register sound when XP gain

Displays

• health bar (upper left, factor 0.1)
• ammo display (lower right, factor 0.3)
• location informations (center, factor 0.6)
• quest updates / messages (upper left, factor 0.6)
• half sized subtitles & conversations (center bottom, factor 0.7)
  

Displays not

• compass/markers/icons
• critical hit gauge
• RADS meter
• AP Display
• explosives amount
• crosshair
• exp gain
• enemy health bars/names/type
• vault boy (perk/condition)
• attackers direction
• enemy grenade warning/location/impact
• power armour low battery warning
  

You can set the HUD color to this to make it even more immersive and less annoying: