So I went through all the ingestibles, set their weight to 0. This includes Syringes for that gun I never use, all drugs, all food (craftable and the Ready-to-eat Blamco Dandy apple Sugar bombs variety). Includes all beverages (thus ingestibles...) and so on. Saved me about 300-400 weight ingame... gosh. Oh this also includes plants/flowers/vegetables. Yay. No 30lbs of melons in your backpack...

All grenades/mines have 0 weight. Because. Annoying.




I don't use NMM so IDK how this is going to look as a download. I manually sort my mods for all games, always have.

Install:
Edit sResourceDataDirsFinal in your fallout4.ini
located here:
%userprofile%\Documents\My Games\Fallout4

How it should look (add any other existing tags you use that aren't listed):
sResourceDataDirsFinal=STRINGS\, textures\, meshes\, scripts\, sound\, music\, misc\, shadersfx\, interface\, programs\, materials\

You may have to set your fallout4.ini to read only for the values to stick. I believe if you touch ingame settings without the file being read only you lose your edited line above which means all your mods will turn off. (if not using NMM, but IDK how to make a mod NMM compatible as I don't use NMM)

Extract the zip (weightless.esp) to your data folder.

Navigate to:
%userprofile%\AppData\Local\Fallout4

This is a hidden folder, make sure you "unhide" hidden folders in your windows settings (Type "show hidden folders" in windows search menu)

Open plugins.txt under all the current lines, add: weightless.esp
Save, exit, play game.