I originally made this simple mod for my own personal use but then realised this really was a good change to the game, so decided to release it :) Taking drugs is now a serious choice with serious consequences, which is much more realistic.

Potent Drugs (Version 1.0 - By TheFakeEmpire)
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Description:
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This simple mod makes the drugs of Fallout 3 much more potent- these being Med-X, Buffout, Psycho, Jet, Ultrajet and Mentats. Alcohol is untouched. Now these drugs will give you greater benefits (nothing too drastic), but their addictions will really hurt you, and they are slightly more easy to become addicted to. Also My First Laboratory now does not cure you of your drug addictions (waaaay too easy), but instead you must go to a doctor (the laboratory can still be used to cleanse yourself of alcohol addictions, and the messages and options screen have been changed accordingly).

The Drugs:
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You are now roughly 25% more likely to develop an addiction to a drug.

Buffout- END+4, STR +3, HP+75 (10 Minutes)
Jet- AP+50 (10 Minutes)
Mentats- INT+5, PER+5 (10 Minutes)
Med-X- DR+25 (10 Minutes)
Ultrajet- AP+75 (10 Minutes)
Psycho- DMG+25% (10 Minutes)

As you can tell some effects have been unaltered (except for the duration), where the original effect was already strong enough.

The Addictions:
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Buffout- END-2, STR-2
Jet- AGL-2, CHR-2
Mentats- INT-2, PER-2
Med-X- AGL-2, INT-2
Ultrajet- AGL-4, PER-2, STR-2
Psycho- END-2, PER-2

Enjoy :)